Asymmetric Henry reaction catalyzed by Cu(I)-based chiral amino alcohol complex

Authors : Tianhua SHEN, Quan QIN, Hang NI, Ting XIA, Xiaocong ZHOU, Funa CUI, Junqi LI, Deqiang RAN, Qingbao SONG

Pages : 966-977

Doi:10.3906/kim-1210-62

View : 17 | Download : 9

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The Cuinsert ignore into journalissuearticles values(I);-based complex prepared from insert ignore into journalissuearticles values(S);-2-insert ignore into journalissuearticles values(furan-2-yl-methylamino);-2-phenylethanol insert ignore into journalissuearticles values(5c); and CuCl was used as catalyst in enantioselective Henry reactions of arylaldehydes and nitromethane, which gave 89% ee and 95% yield at ambient temperature. The proposed catalytic cycle of an asymmetric Henry reaction was suggested.
Keywords : Chiral amino alcohol, copper I, salt, asymmetric catalysis, Henry reaction