VULVA SKUAMÖZ HÜCRELİ KARSİNOMUNDA RADYOTERAPİ SONRASI REKÜRRENS ÖZELLİKLERİ / RECURRENCE PATERNS OF VULVAR SQUAMOUS CELL CARCINOMA FOLLOWED BY RADIOTHERAPY

Authors : Evrim Metcalfe, Durmuş Etiz, Alaaddin Özen, Tufan Öge, Sare Kabukçuoğlu, Sinan Özalp

Pages : 23-28

Doi:10.20515/otd.91977

View : 14 | Download : 12

Publication Date : 2016-01-19

Article Type : Other Papers

Abstract :Özet:  Vulva skuamöz hücreli karsinomu tanısıyla radyoterapi uygulanan hastalarda tedavi sonuçları ve rekürrens özelliklerinin değerlendirilmesi. Ağustos 2006-Ağustos 2014 arasında radyoterapi uygulanan vulva skuamöz hücreli karsinomu tanılı 12 kadın hasta, tümör ve tedavi özelliklerine göre retrospektif olarak değerlendirilmiştir. 3 insert ignore into journalissuearticles values(%25); hastaya radikal, 9’una insert ignore into journalissuearticles values(%75); adjuvan medyan 50.4 insert ignore into journalissuearticles values(30-63); Gy RT uygulanmış, 4 insert ignore into journalissuearticles values(%33); hastaya eşzamanlı kemoterapi verilmiştir. Medyan yaş 65 insert ignore into journalissuearticles values(59-90);; medyan izlem 16 insert ignore into journalissuearticles values(4-65); aydır. Medyan genel, hastalıksız ve uzak metastazsız sağkalım sırasıyla 16 insert ignore into journalissuearticles values(4-65);, 14 insert ignore into journalissuearticles values(0-65); ve 16 insert ignore into journalissuearticles values(4-65); aydır. Hastaların 7’si insert ignore into journalissuearticles values(%58); hastalıksız izlemde olup diğer 5 insert ignore into journalissuearticles values(%42); hastada 1 insert ignore into journalissuearticles values(%8.3); yerel, 2 insert ignore into journalissuearticles values(%17); bölgesel, 1 insert ignore into journalissuearticles values(%8.3); yerel-bölgesel nüks ve 1 insert ignore into journalissuearticles values(%8.3); yerel-bölgesel-uzak hastalık saptanmıştır. Nüks sonrası eksitus olan 3 hastada da inguinal nüks mevcuttur. Vulva skuamöz hücreli karsinomunda sağkalım ve hastalık kontrolünü etkileyen en önemli faktör lenf nodu metastazı olup çalışmamızda nüks gelişen 5 hastadan 4’ünde inguinal lenf nodu metastazı saptanmıştır. ANAHTAR SÖZCÜKLER: vulva kanseri, radyoterapi, prognostik faktörler   RECURRENCE PATERNS OF VULVAR SQUAMOUS CELL CARCİNOMA FOLLOWED BY RADİOTHERAPY Abstract:  Evaluation of treatment outcomes and recurrence paterns of the patients diagnosis with vulvar squamous cell carcinoma treated with radiotherapy. The patients diagnosed by vulvar squamous cell carcinoma between August 2006 and August 2014 were retrospectively evaluated according to tumor and treatment characteristics. Adjuvant radiotherapy was applied three of the twelve patients insert ignore into journalissuearticles values(25%); and radical radiotherapy was applied the other 9 patients insert ignore into journalissuearticles values(75%);.The median radiotherapy dose was 50.4 insert ignore into journalissuearticles values(30-63); Gy. Concurrent chemotherapy is given to 4 patients insert ignore into journalissuearticles values(33%);. Median age was 65 insert ignore into journalissuearticles values(range 59 to 90);; median follow-up time was 16 insert ignore into journalissuearticles values(range 4 to 65); months. The overall survival, relapse-free survival and distant metastasis-free survival were 16 insert ignore into journalissuearticles values(4-65);, 14 insert ignore into journalissuearticles values(0-65); and 16 insert ignore into journalissuearticles values(4-65); months respectively. Seven insert ignore into journalissuearticles values(58%); patients were disease free. One insert ignore into journalissuearticles values(8.3%); local, 2 insert ignore into journalissuearticles values(17%); regional, 1 insert ignore into journalissuearticles values(8.3%); local-regional recurrence and 1 insert ignore into journalissuearticles values(8.3%); local- regional recurrence with distant metastasis were observed. Three patients who had recurrence died with inguinal recurrence. Lymph node metastasis is the most important factor affecting survival and disease control in vulvar squamous cell carcinoma. In our study, four of five patients who developed recurrence had inguinal lymph node metastasis. KEYWORDS: vulvar cancer, radiotherapy, prognostic factors
Keywords : ANAHTAR SÖZCÜKLER vulva kanseri, radyoterapi, prognostik faktörler