The Interaction of Epigenetics In Autoimmune Diseases

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Osmangazi Tıp Dergisi
Volume:45 Issue:3
The Interaction of Epigenetics In Autoimmune Diseases

The Interaction of Epigenetics In Autoimmune Diseases

Authors : Ozel YURUKER, Meis Ceren DURAK, Rasime KALKAN

Pages : 449-454

View : 104 | Download : 72

Publication Date : 2023-05-23

Article Type : Review Paper

Abstract :There have been many important developments in the classification, diagnosis, and finding of new therapies for autoimmune diseases. Current theories suggest that the development of autoimmune diseases involves genetic predisposition, and epigenetic modifications arising from environmental factors, that trigger mainly the adaptive immune pathways that eventually result in tissue destruction. Gene expression can be modified by epigenetic modifications without changing the sequence of the genome. In recent years, it has been identified that epigenetic modifications play role in the pathophysiology of single-gene disease in addition to genetic predisposition. Therefore, understanding the epigenetic factors that contribute to autoimmune diseases may lead to new target-directed therapies. Here, the importance of epigenetic modifications in the pathogenesis of autoimmune diseases and the effect of epigenetic changes on the onset of the disease are summarized.
Keywords : Bağışıklık Toleransı, Epigenetik, Otoimmün Hastalıklar

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