Could the C-reactive protein/albumin Ratio Predict Mortality in Patients with Common Variable İmmunodeficiency?

Authors : Recep EVCEN, Fatih ÇÖLKESEN, Filiz SADİ AYKAN, Mehmet KILINÇ, Eray YILDIZ, Ümmügülsüm YILMAZ ERGÜN, Tuğba ÖNALAN, Fatma Arzu AKKUŞ, Selim KAHRAMAN, Mehmet Emin GEREK, Şevket ARSLAN

Pages : 480-486

Doi:10.20515/otd.1273621

View : 143 | Download : 141

Publication Date : 2023-07-20

Article Type : Research Paper

Abstract :Common variable immunodeficiency insert ignore into journalissuearticles values(CVID); is the most common symptomatic immunodeficiency in adults. This study assessed the utility of using the C-reactive protein insert ignore into journalissuearticles values(CRP);/albumin ratio insert ignore into journalissuearticles values(CAR); at diagnosis to predict mortality in CVID patients. Between 2010 and 2022, hospital records and follow-up cards of patients with CVID were reviewed retrospectively. Seventy-five patients were included in the study. CRP 0–5 mg/L and albumin 3.5–5.5 g/dL were taken as references. The CAR was obtained by dividing the CRP value by the albumin value. Of the included patients, 41 insert ignore into journalissuearticles values(55%); were male and 34 insert ignore into journalissuearticles values(35%); were female. The median age was 38 insert ignore into journalissuearticles values(21–77); years. The mortality rate of the patients during the follow-up time was 20%. Of the patients, 41% had splenomegaly, 10.6% had malignancy, and 39% had bronchiectasis. The cut-off value of CAR to predict mortality was >2.18 insert ignore into journalissuearticles values(sensitivity: 88.4%, specificity: 90.1%);. When the patients were classified according to the CAR, the mortality rate in the patient group with a CAR > 2.18 was statistically significantly higher than the patient group with a CAR ≤ 2.18. The CAR is a cheap, simple, and easily calculated parameter that can predict mortality in CVID patients.
Keywords : Yaygın değişken immün yetmezlik, Albumin, CRP