Clinicopathological Features of Patients with Malignant Melanoma Diagnosis and Prognostic and Predictive Importance of Neuthrophil-Lymphocyte Ratio

Authors : Yasemin SAĞDIÇ KARATEKE, Lütfiye DEMİR, Murat DİNÇER, Bülent YILDIZ

Pages : 651-664

Doi:10.20515/otd.1226498

View : 81 | Download : 54

Publication Date : 2023-09-27

Article Type : Research Paper

Abstract :In this study, the effect of demographic, laboratory and clinicopathological parameters along with neutrophil-lymphocyte ratio insert ignore into journalissuearticles values(NLR); on prognosis and survival and correlation with other parameters was researched in patients with malignant melanoma insert ignore into journalissuearticles values(MM); diagnosis. In our study, 107 patients monitored for MM diagnosis in Eskişehir Osmangazi University Medical Oncology clinic from 2010-2017 were retrospectively assessed. Age, gender, LDH level, pathological parameters, BRAF mutation status, neutrophil-lymphocyte ratio insert ignore into journalissuearticles values(NLR); and the effects of these parameters on overall survival insert ignore into journalissuearticles values(OS); and disease-free survival insert ignore into journalissuearticles values(DFS); and correlations with each other were researched. At time of diagnosis, 86% of patients were in the early stage. The dominant types identified were cutaneous MM and nodular MM. Median NLR cut-off value was identified as 1.97. All non-cutaneous MM cases were BRAF negative insert ignore into journalissuearticles values(p<0.0001);. High NLR was associated with advanced stage insert ignore into journalissuearticles values(p=0.001);, advanced age insert ignore into journalissuearticles values(p=0.008);, ulceration presence insert ignore into journalissuearticles values(p=0.011);, and high mitosis count insert ignore into journalissuearticles values(p=0.05);. High NLR insert ignore into journalissuearticles values(p<0.0001);, high LDH level insert ignore into journalissuearticles values(p=0.04);, increased Breslow thickness insert ignore into journalissuearticles values(p=0.01);, increased Clark level insert ignore into journalissuearticles values(p=0.01);, high mitosis count insert ignore into journalissuearticles values(p=0.02);, and lymph node insert ignore into journalissuearticles values(LN); involvement insert ignore into journalissuearticles values(p=0.04); were correlated with significantly shorter OS durations. Cox multivariate regression analysis identified the most effective independent parameters on OS were LN involvement insert ignore into journalissuearticles values(HR: 3.4, p=0.01); and high NLR insert ignore into journalissuearticles values(HR: 4.6, p=0.04);. Nodal involvement was also identified as the most predictive independent parameter for recurrence insert ignore into journalissuearticles values(HR: 3.2, p=0.03);. In addition to classic parameters, NLR appears to be a biomarker which can predict prognosis. Patients with nodal involvement and high NLR values should be monitored more closely in clinics. Data require support with broad-scale studies.
Keywords : malignant melanoma, NLR, prognostic factors