An Unusual Case; Extragastrointestinal Stromal Tumor of Rectovaginal Septum with Literature Review

Authors : Bülent Yıldız, Yasemin Sağdıç Karateke, Emel Yaldir

Pages : 637-642

Doi:10.20515/otd.1586575

View : 41 | Download : 16

Publication Date : 2025-06-18

Article Type : Other Papers

Abstract :Extragastrointestinal stromal tumors (EGISTs) are tumors that show features of gastrointestinal stromal tumors (GISTs) and are very rare. Extragastrointestinal stromal tumors that originated from female genital tract are more rare. In this case report, we will discuss a case of gastrointestinal stromal tumor originating from the rectovaginal septum. The tumor was surgicaly exised and It was positive for CD117, CD34 and DOG1, immunohistochemicaly. The tumor size was 5.5 cm and the mitotic rate was 20 mitoses per 50 high power field (HPF) and histologic examination revealed focal necrosis . After the surgery, the patient began imatinib 400 mg as adjuvant therapy and still ongoing the therapy. The patient is now healtly without evidence of recurrence 19 months after surgery. Immunohystochemistry and cytogenetics seem to be the most important methods to diagnose EGISTs. After complete surgical resection of the tumour, follow-up with adjuvant imatinib therapy is recommended in high risk disease.
Keywords : Ekstragastrointestinal stromal tümörler, Rektovaginal septum, Genital tract

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