Evaluation of Stromal Fibrosis in Triple-Negative Breast Carcinomas

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Osmangazi Tıp Dergisi
Cilt: 48 Sayı: 1
Evaluation of Stromal Fibrosis in Triple-Negative Breast Carcinomas

Evaluation of Stromal Fibrosis in Triple-Negative Breast Carcinomas

Authors : Nazlı Sena Seker, İlyas Erken, Furkan Albayrak, Beyhan Durak Aras

Pages : 7-12

Doi:10.20515/otd.1757499

View : 26 | Download : 74

Publication Date : 2025-12-15

Article Type : Research Paper

Abstract :Triple-negative breast carcinoma is a subtype of breast cancer characterized by the absence of estrogen and progesterone hormone receptors, as well as HER2 protein expression. It typically exhibits an aggressive clinical course and resistance to treatment. Due to its limited therapeutic options and poor prognostic features, this subgroup holds clinical significance. In recent years, the tumor microenvironment has emerged as a critical area of cancer research, with stromal components gaining attention for their role in tumor progression and treatment resistance. This study retrospectively evaluated the relationship between the size of fibrotic foci observed in the tumor stroma and histopathological prognostic parameters in triple-negative breast carcinoma cases. A total of 26 cases operated between 2018 and 2025, confirmed to be negative for hormone receptors and HER2 protein, were included in the study. Hematoxylin-eosin and Masson\\\'s trichrome-stained slides were examined. The largest stromal fibrotic focus was measured and statistically compared with tumor size, tumor and nuclear grade, Ki-67 proliferation index, lymphovascular invasion, axillary lymph node status, presence of tumor-infiltrating lymphocytes, ductal carcinoma in situ, and necrosis. According to the data obtained, no statistically significant correlation was found between stromal fibrosis size and the prognostic variables examined. However, significant associations were observed between some individual parameters. The findings suggest that further large-scale, multicenter studies are necessary to more clearly determine the prognostic value of stromal fibrosis in triple-negative breast carcinoma
Keywords : Meme neoplazm, Triple negative meme kanseri, Fibrozis

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