Collagen type I alpha 1 (COL1A1) rs1800012 polymorphism in cyclists

Authors : Beste TACAL ASLAN, Başak FUNDA EKEN, Tugba KAMAN, Canan SERCAN, Korkut ULUCAN

Pages : 1-4

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Publication Date : 2020-05-29

Article Type : Research Paper

Abstract :Purpose: We suggested that polymorphic differences affect the performance of cyclists. In this study we designed the experiment to identify collagen type I alpha 1 insert ignore into journalissuearticles values(COL1A1); rs1800012 polymorphism in cyclists.  Methods: We isolated genomic DNA from buccal epithelial cells of 38 cyclists. We followed COL1A1 rs1800012 single nucleotide polymorphism genotyping technology protocol. We reported allele frequencies for rs1800012 gene variants of cyclists in our kohort.  Results: Our results indicated the differences of the distribution of COL1A1 rs1800012 SNP between cyclists. The numbers and percentages of CC, AC and AA genotypes for rs1800012 polymorphism that we obtained were 24 insert ignore into journalissuearticles values(63%);, 13 insert ignore into journalissuearticles values(34%); and 1 insert ignore into journalissuearticles values(3%);, respectively. The distributions of C and A alleles were counted as 61 insert ignore into journalissuearticles values(80%); and 15 insert ignore into journalissuearticles values(20%);. Conclusions: There was difference in the genotype and also allele distribution between cyclists. Carriers of a C allele as compared to carriers of the allele A are more prone to cyclism. Larger homogenous cohorts may help clarify the association between COL1A1 rs1800012 polymorphism and physical performance.
Keywords : collagen type I alpha I, polymorphism, cycling

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