Ruxolitinib use in myelofibrosis patients: the single center experience and the relationship between JAK-2 allele burden and Ruxolitinib response

Authors : Mesut GÖÇER, Erdal KURTOĞLU

Pages : 322-329

Doi:10.31362/patd.770631

View : 21 | Download : 8

Publication Date : 2021-04-01

Article Type : Research Paper

Abstract :Abstract: Purpose: Ruxolitinib is an oral JAK-1/2 inhibitor approved for the treatment of splenomegaly and/or constitutional symptoms in intermediate and high-risk myelofibrosis patients. The aim of our study is to evaluate the efficacy and safety of ruxolitinib in primary MF, post-ET MF and post-PV MF patients, to evaluate the relationship between response and JAK-2 mutation rate and to compare them with literature data. Materials and Methods: In our single centered and retrospective study, we investigated the data of 30 MF patients diagnosed in our clinic between May 2015 and December 2019. We reported demographic features, laboratory values, and spleen sizes. Results: 18 patients insert ignore into journalissuearticles values(60%); with a median age of 67.5 insert ignore into journalissuearticles values(45-78); had primary myelofibrosis. Spleen sizes decreased significantly 3 and 6 months after treatment. Constitutional symptoms have disappeared in 28 patients insert ignore into journalissuearticles values(93.3%);. No association was found between JAK-2 mutation rate and treatment response success. Conclusion: Ruxolitinib MF is very safe and effective to relieve constitutional symptoms and decrease spleen size. Despite JAK-2 inhibition, no linear relationship was found between JAK-2 mutation rate and treatment efficacy.
Keywords : ruksolitinib, etkinlik, jak2 mutasyonu, myelofibrozis, yanıt oranı