Oxidative stress markers in breast cancer

Authors : Özge Fenercioğlu, Giray Bozkaya, Nuriye Uzuncan, Baha Zengel

Pages : 402-411

Doi:10.31362/patd.1388561

View : 138 | Download : 164

Publication Date : 2024-07-05

Article Type : Research Paper

Abstract :Purpose: The aim of this study was to compare serum Total Antioxidant Status (TAS), Total Oxidant Status (TOS), Oxidative Stress Index (OSI) and Ischemia Modified Albumin (IMA) levels in breast cancer patients and healthy women and to determine whether there is a relationship between oxidative stress markers and breast cancer. Materials and methods: Newly diagnosed 106 breast cancer patients at the Bozyaka Training and Research Hospital General Surgery Clinic and 30 healthy women were included in the study. Serum levels of IMA, TAS, TOS were analyzed by spectrophotometric methods. Results: IMA, TOS and OSI values were found significantly higher in the breast cancer group. Although the TAS values in patients with breast cancer were lower than the control group, the difference was not statistically significant. Conclusions: In our study, it was seen that oxidative stress levels increased in breast cancer patients due to decreased TAS, and significantly increased IMA, TOS and OSI results. There was no correlation of histopathologic findings with IMA, TOS and OSI levels in terms of tumor grade and size. Disturbed oxidative stress status and IMA may contribute to the pathogenesis of breast cancer and more comprehensive studies are needed for prognostic value.
Keywords : Meme kanseri, biyobelirteçler, iskemi modifiye albumin, oksidatif stres