DİMETOAT’IN SIÇAN AKCİĞERİNE OLAN HİSTOPATOLOJİK ETKİSİ VE LAUROCERASUS OFFICINALIS ROEM. (KARAYEMİŞ)MEYVESİNİN KORUYUCU ROLÜ

Authors : Ayşe EKEN, Burcu Ünlü ENDİRLİK, Elçin BAKIR, Arzu Hanım YAY, Ayşe BALDEMİR

Pages : 211-215

View : 49 | Download : 9

Publication Date : 2017-12-01

Article Type : Research Paper

Abstract :Dimethoate is one of the most important and widely used organophosphate insecticides on a large number of crops against several pests. The aim of this study was to evaluate the subchronic toxicity of orally administered dimethoate in Wistar albino rat and the ameliorative effect of cherry laurel fruit extract or vitamin C as control, based on the histopathological findings in the lung tissue. For this purpose, animals were divided randomly into six groups of ten rats each and were treated daily by oral gavage for 60 days. Histopathological alterations in the lung tissue section were determined using a light microscope. Dimethoate exposure exhibited severe histopathological changes in the lung sections compared with control group rats. The morphology of the lung seemed to be mostly affected by dimethoate treatment leading to degenerative changes. An increased hemorrhage within the alveoli, necrosis and alveolar edema as well as an infiltration of inflammatory leukocyte were observed. However, pre- and post-treatment with cherry laurel fruit extract or pretreatment with vitamin C to dimethoate administered rats showed an amelioration in the lung injury. In conclusion, treatment with cherry laurel fruit extract or vitamin C may protect against lung toxicity induced by dimethoate exposure
Keywords : Toxicity, dimethoate, lung, histopathology, cherry laurel fruit

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