In Situ Synthesis of Catecholamines-Inorganic Nanoflowers and Enhanced Antimicrobial Activity

Authors : Çağla Çelik Yoldaş, Nilay Ildiz, Sadık Küçükgünay, İsmail Öçsoy

Pages : 488-498

Doi:10.34108/eujhs.1767146

View : 89 | Download : 179

Publication Date : 2025-12-30

Article Type : Research Paper

Abstract :Hybrid nanoflowers synthesized from proteins, enzymes, amino acids and various plant extracts have attracted considerable interest and are used for a variety of purposes. Notably, they exhibit increased stability, as well as enhanced catalytic, antimicrobial and antioxidant activity compared to free molecules. Most synthesis techniques are expected to occur in a solution medium. In this study, we synthesized catecholamine hybrid nanoflowers in situ as a result of a one-day incubation. The in situ catecholamine nanoflower that we synthesized on the surface of a glass exhibits high antimicrobial activity. Thanks to this feature, they have the potential to be used as antimicrobial surface coatings. For surface-bound synthesis, we selected a glass surface as the model surface and catecholamines (dopamine, epinephrine and norepinephrine) as the model organic components. We characterized the in situ catecholamine nanoflower using Scanning Electron Microscopy and contact angle analysis. Additionally, we tested the antimicrobial activities of the in situ catecholamine nanoflower coating against the bacteria Staphylococcus aureus and Escherichia coli and the fungus Candida albicans. The results revealed that the antimicrobial activity of the in situ catecholamine nanoflower coatings had increased significantly. In view of the findings, it is expected that they will have a successful impact as part of antimicrobial surface coatings.
Keywords : Antibakteriyel kaplama, katekolaminler, nano çiçek

ORIGINAL ARTICLE URL