BORIC ACID AMELIORATES LIVER INJURY IN RAT INDUCED BY CYCLOPHOSPHAMIDE

Authors : Gözde Özge ÖNDER, Özge GÖKTEPE, Eda OKUR, Özge CENGİZ MAT, Demet BOLAT, Esra BALCIOĞLU, Arzu YAY

Pages : 210-216

Doi:10.31832/smj.1246705

View : 30 | Download : 31

Publication Date : 2023-06-30

Article Type : Research Paper

Abstract :Introduction: The aim of the current study was to look into any potential ameliorative benefits of boric acid on liver damage in rats caused by cyclophosphamide insert ignore into journalissuearticles values(CTX);. Materials and Methods: Four groups; control, boric acid, CTX, and boric acid + CTX, were created. Female Wistar albino rats were given daily injections of CTX insert ignore into journalissuearticles values(75 mg/kg); to create the liver damage model. Cyclophosphamide insert ignore into journalissuearticles values(75 mg/kg); was administered intraperitoneally, and boron insert ignore into journalissuearticles values(1.3 g/rat/day); was administered by gavage every day for two weeks in the boric acid+CTX group. The histopathological changes were evaluated in ovarian tissue staining with hematoxylin and eosin, masson tricrom, and periodic acid Schiff. We assessed ovarian tissue enzyme activity as malondialdehyde insert ignore into journalissuearticles values(MDA);, superoxide dismutase insert ignore into journalissuearticles values(SOD);, catalase insert ignore into journalissuearticles values(CAT);, and glutathione peroxidase insert ignore into journalissuearticles values(GSH-Px);. Results: Images in the boric acid+CTX group had lower histological evaluations than those in the CTX group under the light microscope. According to the findings, boric acid reduced the levels of malondialdehyde insert ignore into journalissuearticles values(MDA); in the liver tissues. Additionally, boric acid improved the actions of oxidative stress indicators to reduce oxidative stress brought on by CTX and upregulated antioxidant parameters. Conclusion: In conclusion, our study have demonstrated that CTX- induced liver injury can be alleviated by reducing the tissue MDA levels, increasing the liver’s SOD, GSH-Px, and CAT activities. In order to reduce the liver damage caused by CTX, boric acid may be administered as a dietary supplement or functional food.
Keywords : Borik asit, Karaciğer hasarı, Siklofosfamid