Survival, Failure Patterns, and Toxicity Outcomes in Endometrial Cancer Patients Receiving Adjuvant Radiotherapy

Authors : Hatice HALİS, Sedef GÖKHAN AÇIKGÖZ

Pages : 465-471

Doi:10.31832/smj.1309164

View : 26 | Download : 31

Publication Date : 2023-09-30

Article Type : Research Paper

Abstract :Objective: This study aimed to investigate the survival outcomes, recurrence patterns, and treatment-related toxicities of endometrial cancer insert ignore into journalissuearticles values(EC); patients who underwent adjuvant radiotherapy. Materials and Methods: Between January 2012 and December 2021, one hundred fourteen patients who underwent adjuvant radiotherapy with the diagnosis of endometrial cancer were retrospectively analyzed. Cases were evaluated for overall survival insert ignore into journalissuearticles values(OS);, disease-free survival insert ignore into journalissuearticles values(DFS);, local recurrence-free survival insert ignore into journalissuearticles values(LRFS);, cancer-specific survival insert ignore into journalissuearticles values(CSS);, and distant metastasis-free survival insert ignore into journalissuearticles values(DMFS);. Results: Median follow-up was 63 months insert ignore into journalissuearticles values(8 -135);. At 5 years OS, DFS, LRFS, CSS, and DMFS were 85.5%, 90.5%, 98.9%, 94.1%, and 90.5%, respectively. Univariate analysis of lymphovascular space invasion insert ignore into journalissuearticles values(LVSI); is statistically significant for DFS, DMFS, and CSS, respectively insert ignore into journalissuearticles values(p=0.019, p=0.019, p=0.021); and histology, tumor grade, stage were statistically significant for LRFS, respectively insert ignore into journalissuearticles values(p=0.031, p=0.010, p=0.049);. Grade 1 and 2 acute gastrointestinal toxicity were observed in 40 patients insert ignore into journalissuearticles values(35.1%);. Grade 1 acute genitourinary toxicity was observed in 35 patients insert ignore into journalissuearticles values(30.7%);. Grade 3 late genitourinary and gastrointestinal toxicity was observed in 0.9% and 1.8%, respectively. Conclusion: Histology, grade, LVSI, and stage didn’t significantly affect overall survival, but LVSI and stage were the most influential prognostic factors on relapse patterns. Adjuvant radiotherapy is safe and well tolerated by patients with endometrial cancer with acceptable toxicity.
Keywords : Endometrium kanseri, Adjuvan radyoterapi, Sağkalım, Tedaviye bağlı toksisite