HOG tabanlı YSA kullanılarak yağlı karaciğer tedavisindeki ilaç etkinliklerinin hesaplanması

Authors : Nuh Alpaslan, Muhamed Fatih Talu, Mehmet Gül, Birgül Yiğitcan

Pages : 106-112

Doi:10.16984/saufbed.13754

View : 36 | Download : 9

Publication Date : 2012-08-01

Article Type : Research Paper

Abstract :In this work, healing effects of melatonin and resveratrol drugs on liver damage in rats, induced by application of acute and chronic carbon tetrachloride insert ignore into journalissuearticles values(CCl4); have been examined. The study consists of three main stages: 1); Data Acquisition: 60 rats have been separated into 10 groups. Except control groups other eight groups have been injected olive oil, CCL4 insert ignore into journalissuearticles values(make liver fatty);, CCL4+Melatonin, CCL4+Resveratrol drugs regularly and 4 and 20 days after light microscope images of rats have been obtained from liver tissue.2); Data Processing: By the help of histograms of oriented gradient insert ignore into journalissuearticles values(HOG); method, obtaining low-dimensional image features insert ignore into journalissuearticles values(color and shape); and classifying 5 different group characteristics by using these features with artificial neural networks have been provided.3); Calculation of Drug Effectiveness: Firstly to determine the differences between group characteristics of rats, a pilot group has been selected insert ignore into journalissuearticles values(diseased group-CCl4);, and responses of artificial neural networks trained by HOG features have been calculated.As a result, it has been seen that melatonin and resveratrol drugs have %65.62 -%75.12 positive effects at the end of the fourth day, %84.12-%98.89 positive effects on healing steatosis hepatis at the end of the twentieth day respectively.
Keywords : Yapay Sinir Ağları, HOG, Karaciğer Yağlanması, Melatonin, Resveratrol