Farelerde Mikronukleus Testi Kullanılarak Gama Radyasyonu Ve Ağır Metal İyonları Tarafindan Teşvik Edilen Genotoksisitenin Belirlenmesi: Patolojik Değerlendirmeli

Authors : Kültiğin ÇAVUŞOĞLU, Emine YALÇIN, Oğuz KUL, Abdullah YILMAZ, Kürşad YAPAR

Pages : 1-8

Doi:10.16984/saufbed.41625

View : 25 | Download : 14

Publication Date : 2010-06-01

Article Type : Research Paper

Abstract :Micronuclei insert ignore into journalissuearticles values(MN); test is used as markers of radiosensitivity or chemosensitivity. In present study, it was investigated the frequency of MN in erythrocytes and body weight gain in 80 Mus musculus var. albinos exposed to 10 Gy gamma insert ignore into journalissuearticles values(γ); radiation and heavy metal ions. For this aim, it was used MN assay as an indicator of genotoxicity induced by γradiation and heavy metal toxication. The animals were divided into four groups: control, radiation, Hg and Pb treatment groups. They were treated with three dose levels insert ignore into journalissuearticles values(10, 15 and 20 µg/mL); of Hg and Pb metal ions and 10 Gy γradiaton was applied twice during 14 days. The initial and final weights of all mice were determined by sensitive balance in order to investigate the effect of heavy metal ions and radiation on the weight gain of mice. As a result, the frequency of MN was higher in the Hg, Pb and γradiation treated animals than animals in control group. Besides, MN frequency was higher in mice exposed to γradiation than in Hg and Pb treated mice, and differences was statistically significant insert ignore into journalissuearticles values(p
Keywords : Farelerde Mikronukleus Testi Kullanılarak Gama Radyasyonu Ve Ağır Metal İyonları Tarafindan Teşvik Edilen Genotoksisitenin Belirlenmesi Patolojik DeğerlendirmeliKültiğin Çavuşoğlu1, Emine Yalçın1, Oğuz Kul2, Abdullah Yılmaz3, Kürşad Yapar41Giresun Üniv