NMR and DSC studies on the reactions of pentanedioxy spiro-ansa cyclochlorotriphosphazene and pentanedioxy triple-bridged cylochlorotriphosphazene with monofunctional nucleophiles

Authors : Rafig GURBANOV, Murat TUNA, Sedat TÜRE

Pages : 1177-1189

Doi:10.16984/saufenbilder.540276

View : 24 | Download : 12

Publication Date : 2019-12-01

Article Type : Research Paper

Abstract :In this study, the reactions of 2-insert ignore into journalissuearticles values(2-hydroxyethyl); thiophene insert ignore into journalissuearticles values(2); and benzyl alcohol insert ignore into journalissuearticles values(3); with pentanedioxycyclochlorotriphosphazene insert ignore into journalissuearticles values(1); and pentanedioxy triple-bridged cylochlorotriphosphazene insert ignore into journalissuearticles values(6); were studied. The novel cyclotriphosphazene compounds: two di-substituted spiro-ansa, N 3 P 3 [Oinsert ignore into journalissuearticles values(CH 2 ); 5 O]- insert ignore into journalissuearticles values(C 6 H 7 OS);] 2 insert ignore into journalissuearticles values(4); and N 3 P 3 [Oinsert ignore into journalissuearticles values(CH 2 ); 5 O-insert ignore into journalissuearticles values(C 6 H 5 CH 2 O);] 2 insert ignore into journalissuearticles values(5);; and two fully substituted triple-bridged, N 3 P 3 [Oinsert ignore into journalissuearticles values(CH 2 ); 5 O] 3 -insert ignore into journalissuearticles values(C 6 H 7 OS); 6 N 3 P 3 insert ignore into journalissuearticles values(7); and N 3 P 3 [Oinsert ignore into journalissuearticles values(CH 2 ); 5 O] 3 -insert ignore into journalissuearticles values(C 6 H 5 CH 2 O); 6 N 3 P 3 insert ignore into journalissuearticles values(8); derivatives were formed in THF solvent by using NaH base at ambient conditions. Because of their variety of applications, there is a great deal of interest in the preparation of aromatic macrocyclic derivatives of cyclophosphazenes. The main purpose of these studies is to develop bioactive cyclophosphazene derivatives in the search for new effective drug candidates for the treatment of various diseases, in particular, anticancer and antimicrobials. The synthesized compounds insert ignore into journalissuearticles values(4, 5, 7, 8); were defined using analytical techniques namely Element analysis, TLC/MS system, and NMR spectroscopy. Thermal stabilities, crystal purity, and recrystallization properties and corresponding enthalpies of synthesized derivatives were analyzed in the course of heating and cooling cycles of DSC.
Keywords : Cyclophosphazene, spiro ansa compounds, triple bridged compounds, monofunctional nucleophilic reagents, Nuclear magnetic resonance spectroscopy