Synthesis and Characterization of Dimeric Thio-Schiff Bases by Nano Cerium Oxide and Examination of Their Antimicrobial Activities

Authors : Aslıhan DALMAZ, Sefa DURMUŞ, Gorkem DULGER, Başaran DÜLGER

Pages : 364-378

Doi:10.16984/saufenbilder.737671

View : 31 | Download : 15

Publication Date : 2021-04-15

Article Type : Research Paper

Abstract :In this work, firstly, CeO2 nanoparticles, which can be used as catalysts in many reactions, were synthesized by preparing aqueous solution of ceriuminsert ignore into journalissuearticles values(III); nitrate hexahydrate in basic medium. In the second step, the synthesis of dimeric thio Schiff bases was carried out using two different methods. Effect of catalyst on some parameters such as reaction time and yield of product were investigated. The antimicrobial activities of the ligands have been screened in vitro against the organisms Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae insert ignore into journalissuearticles values(Gram negative bacteria);, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Bacillus cereus insert ignore into journalissuearticles values(Gram positive bacteria); and Candida albicans, C. tropicalis, C. guilliermondii, C. glabrata by Disc Diffusion and Microdilution methods. At the same time, antimicrobial activities of ligands were compared to standard antibiotics insert ignore into journalissuearticles values(Cefotaxime, Amoxicillin/clavulanic acid, Posacanazole, Nystatin and Gentamicin);. Generally, the results obtained in this research showed that all tested ligands exhibited more effect towards Gram positive bacteria and Candida species as compared to standard antibiotics.
Keywords : Anti bacterial, Anti candidal, Ceria, Disulphide Schiff bases, Nanocatalyst