Obez hastalarda kısa dönem (1 aylık) orlistat tedavisinin plazma lipid düzeylerine etkisi

Authors : Ercan VAROL, Mehmet ŞAHİN, Smurat ASLAN, Mehmet ÖZAYDIN, Ahmet ALTINBAŞ

Pages : 1-3

Doi:10.17343/sdutfd.57521

View : 22 | Download : 7

Publication Date : 2009-04-21

Article Type : Research Paper

Abstract :SüleymanDemirel Üniversitesi TIP FAKÜLTESİ DERGİSİ: 2006 Eylül; 13insert ignore into journalissuearticles values(3); Obez hastalarda kısa dönem insert ignore into journalissuearticles values(1 aylık); orlistat tedavisinin plazma lipid düzeylerine etkisi Ercan Varol, Mehmet Şahin, S Murat Aslan, Mehmet Özaydın, Ahmet Altınbaş Özet Obez hastalarda kısa dönem insert ignore into journalissuearticles values(1 aylık); orlistat tedavisinin plazma lipid düzeylerine etkisi Kısa dönem, 1 aylık orlistat tedavisinin lipid profili üzerine etkisini araştırmak. Onüç obez hastada düşük kalorili diyete ilave olarak günde 3 kez 120 mg orlistat verildi. Başlangıç ve 1 ay sonraki plazma lipid düzeylerine bakıldı. Trigliserid insert ignore into journalissuearticles values(TG); seviyesi 169.9 ± 62.7 mg/dl den 156.6 ± 60.4 mg/dl`ye insert ignore into journalissuearticles values(p<0.05);, düşük dansiteli lipoprotein kolesterol insert ignore into journalissuearticles values(LDL-K); seviyesi 137.7 ± 17.5 mg/dl den 136.1 ± 17.2 mg/dl`ye insert ignore into journalissuearticles values(p<0.05); ve total kolesterol insert ignore into journalissuearticles values(TK); seviyesi 222.1 ± 47.3 mg/dl den 220.8 ± 47.6 mg/dl seviyesine düştü insert ignore into journalissuearticles values(p<0.05);. Azalmalar istatistiksel açıdan anlamlı idi. Yüksek dansiteli lipoprotein kolesterol insert ignore into journalissuearticles values(HDL-K); seviyesindeki artış anlamlı değildi insert ignore into journalissuearticles values(36.5 ± 2.7 mg/dl den 36.9 ± 2.4 mg/dl` ye; p=0.09);. Orlistat kilo verdirici etkisinden bağımsız olarak 1 aylık kısa dönemde lipid profili üzerine olumlu etkiye sahiptir. Anahtar kelımeler: Obezite, Orlistat, Kolesterol, Trigliserid Abstract Effect of short term insert ignore into journalissuearticles values(1 month); orlistat treatment on plasma lipid levels ın obese patients The aim of the study is to investigate the effect of a short term 1–month orlistat treatment on lipid profile in obese patients. Orlistat was administered three times 120 mg in a day in conjunction with a reduced calorie diet in 13 obese patients. Plasma lipid levels were determined at beginning and 1 month later. The triglyceride level decreased from 169.9 ± 62.7 mg/dl to 156.6 ± 60.4 mg/dl insert ignore into journalissuearticles values(p<0.05);, low density lipoprotein cholesterol level decreased from 137.7 ± 17.5 mg/dl to 136.1 ± 17.2 mg/dl insert ignore into journalissuearticles values(p<0.05); and total cholesterol level decreased from 222.1 ± 47.3 mg/dl to 220.8 ± 47.6 mg/dl insert ignore into journalissuearticles values(p<0.05);. The changes were statistically significant. The increase in high density lipoprotein cholesterol levels was not statistically significant insert ignore into journalissuearticles values(36.5 ± 2.7 mg/dl to 36.9 ± 2.4 mg/dl; p=0.09);. Orlistat has a beneficial effect on lipid profiles in 1 month short term period in obese patients regardless of weight loss. Key words: Obesity, Orlistat, Cholesterol, Triglyceride
Keywords : Obezite, Orlistat, Kolesterol, Trigliserid