COMPARISON OF THE EFFECTS OF CLINICOPATHOLOGICAL AND RADIOLOGICAL FINDINGS ON SURVIVAL IN WOMEN YOUNGER THAN 40 YEARS AND OLDER THAN 55 YEARS OF AGE WITH BREAST CANCER

Authors : Buket ALTUN ÖZDEMİR, Servet KOCAÖZ, Bülent ÇOMÇALI, Mustafa Ömer YAZICIOĞLU, Fırat CANLIKARAKAYA, Cengiz CEYLAN, Birol KORUKLUOĞLU

Pages : 37-45

Doi:10.17343/sdutfd.1182177

View : 26 | Download : 12

Publication Date : 2023-03-14

Article Type : Research Paper

Abstract :Objective Tumors of women with breast cancer show clinical and biological differences depending on the hormonal changes that develop with age. Therefore, in this study, we compared the radiologic, and clinicopathological features of breast cancer patient’s < 40 age and ≥55 age. Material and Method The files of a total of 759 patients, including 92 patients under 40 aged, and 322 patients 55 aged and over who were operated on for breast cancer over a 10-year period in three centres were retrospectively reviewed and Estrojen Reseptor insert ignore into journalissuearticles values(ER);, Progesteron Reseptor insert ignore into journalissuearticles values(PR);, Human epidermal growth factor receptor 2 insert ignore into journalissuearticles values(HER2);, Lymphovascular invasion insert ignore into journalissuearticles values(LVI); status, presence of axillary lymph node metastasis insert ignore into journalissuearticles values(ALNM);, multifocality, presence of Ductal Carsinoma İnsitu insert ignore into journalissuearticles values(DCIS); or Lobular Carsinoma İnsitu insert ignore into journalissuearticles values(LCIS);, tumor size, tumor histopathological type, grade, and score were recorded. Results In patients under the age of 40, the tumor is less localized in the upper-inner and lower-inner quadrants of the breast, multifocality is more common, most of them have dense breast structure, the histological grade of the tumor is higher, LVI and LNM are more common. It was found that they had ER receptor positivity and higher Ki-67 proliferation index insert ignore into journalissuearticles values(p<0.001, p<0.001, p<0.001, p<0.001, p=0.021, p=0.039, p=0.001 and p<0.001, respectively);. It was observed that the multifocality and density of breast tissue were lower in tumors in patients under 55 years of age insert ignore into journalissuearticles values(p = 0.002, p <0.001, respectively);. Luminal B and TN were more common among molecular subtypes in patients under 40 years of age, while luminal A subtype was more common in patients over 55 years of age insert ignore into journalissuearticles values(p<0.001, p=0.001, respectively);. Conclusion Clinicopathological differences between <40 aged, and 55 aged and over patients were confirmed. Adverse prognostic factors for breast cancer at the age of under 40 patients were revealed.
Keywords : Meme Kanseri, Lenfovaskuler invazyon, Lenf nodu metastazı, Moleküler alt tip, Meme yoğunluğu