THE MMP9 −1562 C/T POLYMORPHISM IS ASSOCIATED WITH INCREASED RISK OF DIABETIC RETINOPATHY IN TURKISH TYPE 2 DIABETES MELLITUS PATIENTS

Authors : Fadime MUTLU İÇDUYGU, Egemen AKGÜN, Ebru ALP, Sibel DOĞUİZİ, Murat Atabey ÖZER

Pages : 217-224

Doi:10.17343/sdutfd.1268838

View : 33 | Download : 47

Publication Date : 2023-06-22

Article Type : Research Paper

Abstract :Objective Type 2 diabetes mellitus insert ignore into journalissuearticles values(T2DM); and diabetic retinopathy insert ignore into journalissuearticles values(DR); development is affected by genetic factors. Matrix metalloproteinases insert ignore into journalissuearticles values(MMPs); are involved in many cellular processes, such as remodeling of extracellular matrix proteins and angiogenesis. In this study, we investigated the relationship between MMP9 −1562 C/T insert ignore into journalissuearticles values(rs3918242); polymorphism and the development of T2DM and DR in Turkish population. Material and Method A total of 510 participants, involving 168 T2DM cases with DR, 168 T2DM cases without DR, and 174 controls, were included in the study. The polymerase chain reaction-restriction fragment length polymorphism insert ignore into journalissuearticles values(PCR-RFLP); method was carried out to identify genotypes. Results The CT, CT+TT genotypes and the T allele of the MMP9 −1562 C/T polymorphism were associated with increased risk of DR insert ignore into journalissuearticles values(p=0.001);. On the other hand, no relationship was found between the development of T2DM and this polymorphism. In addition, CT insert ignore into journalissuearticles values(p=0.010); and CT+TT insert ignore into journalissuearticles values(p=0.015); genotype frequencies were found to be higher in proliferative diabetic retinopathy insert ignore into journalissuearticles values(PDR); cases compared to nonproliferative diabetic retinopathy insert ignore into journalissuearticles values(NPDR); cases, but after regression analysis, only insulin use insert ignore into journalissuearticles values(p=0.003); was found to be associated with the development of PDR. Conclusion Our data show that the MMP9 −1562 C/T polymorphism is associated with the development of DR in Turkish T2DM patients, but no significant relationship was found between this polymorphism and the severity of DR and the development of T2DM.
Keywords : Diabetik retinopati, MMP9, Polimorfizm, Proliferatif diyabetik retinopati, Tip 2 diabetes mellitus