Novel Furan-Imine Substituted Zinc Phthalocyanine with Increased Singlet Oxygen Formation by Sono-Photochemical Method

Authors : Gürkan Karanlık

Pages : 44-53

Doi:10.19113/sdufenbed.1599212

View : 27 | Download : 36

Publication Date : 2025-04-25

Article Type : Research Paper

Abstract :This work aims to show the relationship between photochemical and sonophotocehmical features of novel zinc phthalocyanine having furan-imine substituent along with synthesis and characterization of complex (3). Both photochemical and sono-photochemical techniques were applied in order to calculate and compare the singlet oxygen quantum yield of the complex (3) in DMSO. The singlet oxygen quantum yield of the complex (3) was determined as 0.12 by the PDT method (irradiated with only light), while the value of 0.78 was reached by the SPDT approach (combination of light and ultrasound). Considering the efficiency in singlet oxygen formation, it can be said that the SPDT modality is a more powerful therapeutic solution than the PDT technique and also the complex (3) may be a suitable sono/photosensitizer candidate in both PDT and SPDT tecniques. This study will also contribute to the field on enhancing singlet oxygen generation by using SPDT approach.
Keywords : Fotodinamik terapi, Sonofotodinamik terapi, Singlet oksijen kuantum verimi, Çinko ftalosiyanin