The effect of the overweight on the circulating cytokines and adipokines

Authors : Zuhal Yetkin Ay, Fethiye Çağlar Özşahin, Duygu Kumbul Doğuç, Birsen Harun Dağdeviren, Ersin Uskun, Fatma Yeşim Kırzıoğlu

Pages : 24-30

View : 27 | Download : 9

Publication Date : 2017-01-03

Article Type : Research Paper

Abstract :Objective: Interleukin insert ignore into journalissuearticles values(IL);-1β, IL-4, IL-6, and tumor necrosis factor insert ignore into journalissuearticles values(TNF-α); are forefront cytokines in the periodontitis pathogenesis. Therefore, this study aimed to test the hypothesis that overweight rats with periodontitis have higher pro-inflammatory cytokines and/or adipokines, and lower anti-inflammatory cytokines and/or adipokines in serum than normal weight rats. Material-Method: Thirty-two 4-month old male Wistar rats were divided into 4 groups: normal weight, periodontally healthy rats insert ignore into journalissuearticles values(NH, n = 8);, normal weight rats with periodontitis insert ignore into journalissuearticles values(NP, n = 8);, overweight, periodontally healthy rats insert ignore into journalissuearticles values(OH, n = 8);; and overweight rats with periodontitis insert ignore into journalissuearticles values(OP, n = 8);. Periodontitis was induced by ligature for 14 days. The serum cytokine’ and adipokine’ levels were investigated using ELISA. Results: IL-4 levels were higher in the NH and NP groups than their counterparts in the overweight rats insert ignore into journalissuearticles values(P <0.01);. The IL-6 level was significantly higher in the OP group than in the NP group insert ignore into journalissuearticles values(P < 0.01);. The adiponectin level was significantly higher in the NH group than in the OH and OP groups insert ignore into journalissuearticles values(P < 0.01);. Leptin and resistin levels didn’t differ significantly among the groups insert ignore into journalissuearticles values(P > 0.01);. Conclusions: The overweight status affected the cytokine’ and adipokine’ level independent from the periodontal status in this experimental model. Overweight rats with and without periodontitis have lower serum levels of anti-inflammatory cytokine and adipokines insert ignore into journalissuearticles values(IL-4 and adiponectin); and higher serum levels of pro-inflammatory cytokine insert ignore into journalissuearticles values(IL-6); than their counterparts in normal weight rat groups.
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