Familial hypercholesterolemia in Türkiye: A comprehensive narrative review of the literature

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Anadolu Kliniği Tıp Bilimleri Dergisi
Cilt: 31 Sayı: 1
Familial hypercholesterolemia in Türkiye: A comprehensive narrative review of the literature

Familial hypercholesterolemia in Türkiye: A comprehensive narrative review of the literature

Authors : İdris Baydar, Davut Sakız

Pages : 190-199

Doi:10.21673/anadoluklin.1691236

View : 66 | Download : 302

Publication Date : 2026-01-24

Article Type : Review Paper

Abstract :Aim: Familial Hypercholesterolemia (FH); a genetic disorder characterized by elevated LDL (low-density lipoprotein) cholesterol levels; is a significant risk factor for premature cardiovascular disease (CVD). Heterozygous FH (HeFH) is particularly underdiagnosed and undertreated worldwide; including in Turkey. This review aimed to evaluate the current status and characteristics of FH in Turkish population; highlighting potential differences from global trends. Methods: To determine the current status of familial hypercholesterolemia in Turkey; PubMed (MEDLINE); Embase; Google Scholar; the Turkish Higher Education Council Thesis Center; and the Web of Science databases were searched. Results: The literature review conducted to assess the current status of FH in Turkey revealed a lack of sufficient studies providing comprehensive data on the condition within the country. The results of studies indicate that the prevalence of FH in Turkey might be higher than the global average; possibly due to genetic and environmental factors unique to the region. Additionally; Turkish patients with FH were found to have a higher burden of untreated LDL cholesterol and an earlier onset of CVD symptoms compared to global reports. These findings underscore a substantial gap in early detection and treatment strategies for FH in Turkey. Conclusion: This study suggests the urgent need for improved screening programs; public awareness campaigns; and tailored therapeutic interventions to address the FH burden in Turkey. By highlighting regional variations; this research contributes to the broader understanding of FH and emphasizes the importance of global collaboration in tackling this silent but impactful condition.
Keywords : Ailesel hiperkolesterolemi, ateroskleroz, dislipidemiler, genetik, heterozigot, homozigot

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