The impact of therapeutic antibiotic use in childhood on the risk of precocious puberty

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Anadolu Kliniği Tıp Bilimleri Dergisi
Cilt: 30 Sayı: 3
The impact of therapeutic antibiotic use in childhood on the risk of precocious puberty

The impact of therapeutic antibiotic use in childhood on the risk of precocious puberty

Authors : Leyla Kara

Pages : 435-445

Doi:10.21673/anadoluklin.1660251

View : 34 | Download : 79

Publication Date : 2025-09-25

Article Type : Research Paper

Abstract :Aim: Early pubertal development (precocious puberty) in girls is associated with genetic, metabolic, and environmental factors. Although it is thought that antibiotics used in early childhood may affect pubertal timing due to their impact on the gut microbiota, there is no definitive evidence on this subject. The aim of this study is to investigate the relationship between antibiotic use characteristics (age at first use, frequency of use, types of antibiotics) in girls with and without early pubertal development. Methods: The study included 122 girls aged 6–8 years. Participants were divided into Early Puberty, Premature Thelarche, and Control groups based on clinical, hormonal, and radiological assessments. Antibiotic use data were obtained from national prescription records. Differences in antibiotic use between groups and correlations with pubertal parameters were analyzed statistically. Results: The pubertal group showed higher body weight, BMI, basal luteinizing hormone (LH) levels, and advanced bone age compared to the control group (p 0.05). A weak positive correlation was found between age at first antibiotic use and bone age in the Premature Thelarche group. Amoxicillin-clavulanic acid was the most frequently prescribed antibiotic, and all participants had a history of antibiotic use. Conclusion: In this study, no differences were observed in antibiotic use characteristics between girls with and without early pubertal development. Genetic and metabolic factors are believed to play a more decisive role in precocious puberty. Longitudinal studies including microbiome analyses and environmental exposures are necessary to better understand these complex relationships.
Keywords : Antibiyotikler, çevresel sorunlara maruziyet, erken puberte, kemik yaşı, mikrobiyom, pediatri

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