Investigation of Genotoxic, Antimicrobial and Antioxidant Activities of Leaf and Flower Extracts of Cynara syriaca Boiss

The mutagenicity and antimutagenicity of leaves and flower extract of Cynara syriaca Boiss were studied with Ames  assay in Salmonella typhimurium TA98 and TA100 strains. While leaves extract did not show any mutagenic effects  against all the tester strains with or without metabolic activation, the flower extract showed mutagenic effect against TA98  strain without metabolic activation. On the other hand, it has been observed that the extracts have antimutagenic activity  against mutations induced by sodium azide and daunomycin. The antimicrobial activity of extracts was determined by  disc diffusion and MIC value. Both of the extracts possess weak antimicrobial activity. Cupric reducing antioxidant  capacity insert ignore into journalissuearticles values(CUPRAC);, DPPH free radical scavenging activity, and ABTS radical cation decolorization methods were  carried out to determine the antioxidant activity. Among the tested antioxidant methods, the highest antioxidant capacity  was determined in ABTS radical cation decolorization assay in which both of the extracts exhibited the best effect.  Flower extract exhibited higher activity also in DPPH free radical scavenging.