Evaluation of Kidney Functions in Patients with Cirrhosis

Authors : Ahmet Uyanıkoğlu, Süleyman Sari

Pages : 31-35

View : 24 | Download : 34

Publication Date : 2025-03-18

Article Type : Research Paper

Abstract :Introduction: Renal functions are frequently impaired in patients with cirrhosis. In this study, it was aimed to evaluate kidney functions in patients with cirrhosis. Materials and Methods: The cross-sectional study were included 321 cirrhosis patients. Imaging, laboratory, and clinical approaches were used to diagnose cirrhosis. The Modification of Diet in Renal Diseases Study (MDRD) formula, which is based on serum creatinine, was used to calculate glomerular filtration rate (GFR). Results: Of 321 cirrhotic patients, 189 (58%) were male, mean age was 55.6 ± 15.1 years, age range was 18-91 years. While 116 (36%) of the patients were compensated, 205 (64%) were decompensated. Etiological causes of cirrhosis 134 (42%) hepatitis B, 98 (30%) cryptogenic, 46 (14%) hepatitis C, 10 Wilson (3%), 10 delta hepatitis (3%), 23 (8%) other causes (alcoholic cirrhosis, cardiogenic cirrhosis, Budd-Chiari, biliary cirrhosis etc.). The mean GFR of the patients was 96.2 ± 27.8 ml/min. While GFR was within the normal range in 205 patients (63%), it was below the normal range in 118 (37%) patients. Of the patients with low GFR, 87 (73%) were at stage 1, 23 (20%) were at stage 2, 6 (5%) were at stage 3 and 2 (2%) were at the limit of end-stage renal disease. Conclusion: The most common etiological cause in our region in patients with cirrhosis is hepatitis B, cryptogenic in the second place and hepatitis C in the third place. Nearly two-thirds of the patients had decompensated cirrhosis, and at least one-third of all cirrhotic patients had kidney injury.
Keywords : siroz, böbrek hasarı, glomerüler filtrasyon hızı