Reversible bilateral postauricular adult seborrheic dermatitis due to sodium valproate-valproic acid combination

Authors : Mehmet Hamdi Örüm, Dilek Örüm, Osman Çevik

Pages : 82-86

Doi:10.55665/troiamedj.1426438

View : 32 | Download : 12

Publication Date : 2024-05-31

Article Type : Other Papers

Abstract :The combination of sodium valproate-valproic acid, commonly used to treat epilepsy and bipolar disor-der, may result in cutaneous reactions. In this case report, we presented a bilateral postauricular sebor-rheic dermatitis associated with sodium valproate-valproic acid use. A sodium valproate-valproic acid combination was introduced to the therapy of a 68-year-old male patient who had been diagnosed with schizophrenia and was on clozapine in order to potentially avoid seizures associated to the medication. On the fifteenth day of drug addition, crusting appeared on the back skin of both ears of the patient. While the patient had a history of clozapine use, there was no history of sodium valproate use or similar cutaneous symptoms. The current condition was associated with the sodium valproate-valproic acid combination and the drug was discontinued. Following discontinuation of the medication, the crusting decreased and disappeared completely after two weeks. The patient\'s schizophrenia-related treatment was completed and he was discharged. No cutaneous reaction was observed again during follow-up. It should be noted that cutaneous reactions may be associated with the use of sodium valproate-valproic acid combination.
Keywords : Sodium valproat, valproik asit, yan etkiler, seboreik dermatit