Evaluation of the effects of ribavirin and proanthocyanidin on the clinical outcome, hematological and biochemical parameters, and viral shedding in canine distemper

Authors : Şükrü DEĞİRMENÇAY

Pages : 125-135

Doi:10.46810/tdfd.1244940

View : 105 | Download : 13

Publication Date : 2023-03-27

Article Type : Research Paper

Abstract :This study investigated the effects of ribavirin, proanthocyanidin, and ribavirin-proanthocyanidin in dogs naturally infected with canine distemper virus insert ignore into journalissuearticles values(CDV);. Five groups were created, each with six dogs aged 2-6 months: one healthy control group and four patient groups. For ten days, the A group received classical treatment insert ignore into journalissuearticles values(CT); [fluid treatment and antibiotic], the A+R group received CT + ribavirin, the A+P group received CT + proanthocyanidin, A+R+P group received CT + ribavirin-proanthocyanidin. On days T0, T3, T7, and T10, hematological, biochemical, and clinical scores were done. These days and the fifth and tenth post-treatment days were also screened for CDV. Clinical improvement was best in the A+P, A+R, A, and A+R+P groups, respectively. The A+R group had fewer leucocytes, neutrophils, and monocytes insert ignore into journalissuearticles values(P<0.05);. CK and CK-MB activity were significantly higher only in the A group insert ignore into journalissuearticles values(P<0.01);, and decreased only in the A+R group as therapy progressed. CREA values were high in A+P and A+R groups insert ignore into journalissuearticles values(P<0.01);. The lowest Ca value was in the A+R group insert ignore into journalissuearticles values(P<0.01);. The least CDV presence was detected in the A+R group regarding viral shedding. As a result, using ribavirin or proanthocyanidin helped to lessen the severity of clinical findings, increase survival, and reduce viral shedding in dogs with CDV.
Keywords : antiviral ajanlar, canine distemper virus, proantosiyanidinler, ribavirin

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