Effects of thymoquinone against D- galactose and aluminum chloride induced testicular dysfunction in rats.

Authors : Serkan Ali AKARSU, Gökhan Doğukan AKARSU, Aysun ÇETİN

Pages : 99-104

Doi:10.46810/tdfd.1291880

View : 159 | Download : 51

Publication Date : 2023-09-27

Article Type : Research Paper

Abstract :Alzheimer\`s disease affects all tissues negatively. In this study, it was aimed to determine the effects of TQ on testicular toxicity in rats with experimental Alzheimer\`s disease. In the study, 33 Wistar Albino rats weighing 190-230 gr were used. Rats were 11 rats in each group; were divided into 3 equal groups as control, ALZ and ALZ+TQ. The control group was given saline by IP route for 28 days daily. The ALZ group was given 60 mg/kg D-gal + 40 mg/kg AlCl3 IP for 28 days daily. The ALZ+TQ group was given 60 mg/kg D-gal + 40mg/kg AlCl3 for 28 days by IP + 20 mg/kg TQ by oral gavage for last 14 days daily. According to the findings of our study, a decrease in SOD, CAT, GPx activity and GSH levels and an increase in MDA levels were determined in the ALZ group. In the ALZ+TQ group, while SOD, GPx, CAT activities and GSH levels increased, MDA levels decreased. Semen analyzes showed that there was a decrease in sperm motility and sperm density in the ALZ group, and an increase in the rate of abnormal sperm and dead spermatozoa. In the ALZ+TQ group, sperm motility, abnormal sperm rate and dead spermatozon rate improved. As a result, it was determined that the decrease in semen quality and increase in oxidative stress induced by AlCl3+D-Gal were suppressed by TQ, protecting the testicular tissue from oxidative damage and increasing semen quality.
Keywords : Alzheimer, AlCl3 D Galaktoz, oksidatif stres, rat, sperm, timokinon

ORIGINAL ARTICLE URL