In Vitro Cytotoxic Effects of Some Fumaria L. (Papaveraceae) Species Methanolic Extracts on Cancer Cell Lines

Authors : Pelin Yılmaz Sancar, Irmak Icen Taskın

Pages : 25-29

Doi:10.46810/tdfd.1287018

View : 127 | Download : 54

Publication Date : 2024-06-28

Article Type : Research Paper

Abstract :The Fumaria L. species (Papaveraceae), is known colloquially as “Şahtere”. This species, which has been proven to contain significantly rich components, is used by people to treat a number of different diseases. This study investigated the cytotoxic effects of the methanolic extracts of above-ground portions of Fumaria asepala Boiss. and Fumaria schleicheri Soy.-Will. subsp. microcarpa Boiss. ex Hausskn. taxons against Beas-2B, sh-sy5, HCT116 and A549 cell lines. The changes in cancer cell vitality were identified using the 3-(4.5-dimethylthiazol -2-il)-2.5-diphenyltetrazolium bromide (MTT). While the results showed that F. asepala and F. schleicheri subsp. microcarpa\'s methanolic extracts presented a meaningful decrease in the vitality of colon (HCT-116) cancer cells, no cytotoxic effect was achieved on lung (A549) cancer and brain (sh-sy5) cancer cells. Also, the herbal extracts did not create any toxic effect on healthy lung cells (Beas-2B).
Keywords : Fumaria, Sitotoksik, Beas 2B, sh sy5, HCT116, A549

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