Investigation of Radiation Interaction Parameters of Anti-Human Immunodeficiency Virus Drugs in Wide Energy Region

Authors : Ugur Akbaba, Kübra Kamacı, Erdem Şakar

Pages : 204-212

Doi:10.46810/tdfd.1614991

View : 105 | Download : 53

Publication Date : 2025-06-27

Article Type : Research Paper

Abstract :Human Immunodeficiency Virus (HIV) positive patients are exposed to radiation therapy for the treatment of various types of cancer. During these treatments, it is inevitable that radiation will interact with the antiviral drugs used. Determining the radiation attenuation parameters of drugs used in HIV treatment is therefore considered essential. In this context, the radiation attenuation capabilities of the HIV drugs were analyzed based on the parameters mass attenuation coefficient (MAC), atomic cross section (ACS), electronic cross section (ECS), effective atomic number (Zeff), exposure build-up factor (EBF) and energy absorption build-up factor (EABF). The values were investigated in the 0.015-15 MeV range using the Phy-X/PSD software. The build-up factors were also analyzed using the geometric progression (G-P) method up to a penetration depth of 40 mean free path (MFP). Based on the results, Efavirenz and Indinavir were found to have the highest and lowest radiation reduction capacities, respectively. It is believed that these findings can be used to make medical processes more beneficial.
Keywords : Anti-HIV ilaçları, , Radyasyon zayıflaması, Radyasyon-madde etkileşimi, Kanser tedavisi, Phy-X/PSD yazılımı

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