EVALUATION OF INSULIN RESISTANCE IN PATIENTS WITH PREMATURE ADRENARCHE

Authors : Nurullah ÇELİK, Gülşah ÜNSAL

Pages : 1-6

Doi:10.51972/tfsd.1144735

View : 18 | Download : 7

Publication Date : 2023-01-31

Article Type : Research Paper

Abstract :Purpose: There is a conflicting result in terms of insulin resistance insert ignore into journalissuearticles values(IR); in children with Premature Adrenarche insert ignore into journalissuearticles values(PA);. The study aimed to investigate the IR and Trıglycerıde-Glucose insert ignore into journalissuearticles values(Ty-G); index in patıents wıth PA. Material and Methods: This cross-sectional study was conducted in a tertiary pediatric endocrinology clinic with 160 children aged 6-8 years old. The study group insert ignore into journalissuearticles values(n=75); were selected cases diagnosed with PA. Seventy-nine age and sex-matched children were also selected as a control group. Ty-G İndex, Homeostasis Model of Insulin Resistance insert ignore into journalissuearticles values(HOMA-IR);, and atherogenic index of plasma insert ignore into journalissuearticles values(AIP); were calculated. Results: Trıglycerıde-Glucose index, AIP, and HOMA-IR were similar insert ignore into journalissuearticles values(p>0.05);. Ty-G İndex was positively correlated with AIP insert ignore into journalissuearticles values(r=0.61, p<0.001);, BMI-SDS insert ignore into journalissuearticles values(r=0.26, p=0.002);, and HOMA-IR insert ignore into journalissuearticles values(r=0.33, p<0.001); levels. The DHEA-S level was correlated with the AIP insert ignore into journalissuearticles values(r=0.24, p=0.005);, and BMI-SDS insert ignore into journalissuearticles values(r=0.17, p=0.03); levels. BMI-SDS was correlated wtih HOMA-IR insert ignore into journalissuearticles values(r=0.28, p=0.02); levels. Conclusion: Non-obese children with PA have similar IR parameters compared with control groups. Therefore, additional evaluation for IR parameters in lean children with PA is not required.
Keywords : Premature Adrenarche, Insulin Resistance, Triglyceride Glucose index, Homeostasis Model of Insulin Resistance, Plasma atherogenic index