Cutaneous Ulceration Associated with Subcutaneous Interferon Beta 1a Injection

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Türkiye Çocuk Hastalıkları Dergisi
Volume:12 Issue:4
Cutaneous Ulceration Associated with Subcutaneous Interferon Beta 1a Injection

Cutaneous Ulceration Associated with Subcutaneous Interferon Beta 1a Injection

Pages : 280-282

View : 59 | Download : 9

Publication Date : 2018-12-30

Article Type : Other Papers

Abstract :Subcutaneous interferon beta 1a insert ignore into journalissuearticles values(IFN β 1a); has been shown to reduce relapse rates in patients with relapsing-remitting multiple sclerosis. We report the occurrence of severe necrotizing cutaneous reactions in a 19-year-old girl. She self injected IFN β 1a three times a week on the abdomen and both thighs. Treatment was initially well tolerated, but she described erythematous patches and local pain at the injection sites recently. The areas on the abdomen became violaceous with necrotic ulcers. Her therapy was changed to 0.5 mg fingolimod. The lesions began to improve and cicatrize after several weeks with postinflammatory hyperpigmentation. Early recognition of severe local adverse reactions and correction of the injection technique is important.
Keywords : Interferon beta 1a

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