An Oxidative Stress Marker in Pediatric Migraine Patients: Dynamic Thiol-Disulfide Homeostasis

Authors : Derya CENSUR, Deniz YILMAZ, Didem ARDIÇLI, Hakan CENSUR, Aslı ÇELEBİ TAYFUR, Özcan EREL

Pages : 1-6

Doi:10.12956/tchd.1041332

View : 33 | Download : 10

Publication Date : 2023-01-30

Article Type : Research Paper

Abstract :Objective: Migraine is a common disease in childhood. Oxidative stress has been implicated in the pathogenesis of migraine. Dynamic thiol/disulfide homeostasis is proven to be a marker of oxidative stress. We aimed to investigate the correlation between migraine and dynamic thiol/disulfide homeostasis. Material and Methods: A total of 141 children insert ignore into journalissuearticles values(71 migrain and 70 controls); were included. The serum total thiol, native thiol, and disulfide levels were measured and the ratios of disulfide/native thiol, disulfide/total thiol and native thiol/total thiol were compared between migraine patients and healthy children during attack-free period. Results: Native thiol levels and native thiol/total thiol ratio were significantly lower in the migraine group than the control group insert ignore into journalissuearticles values(p=0.022, p=0.005, respectively);; whereas disulfide levels, disulfide/native thiol and disulfide/total thiol ratios were significantly higher in the migraine group than the control group insert ignore into journalissuearticles values(p=0.039, p=0.022, p=0.005 respectively);. Conclusion: Our results demonstrate that there is an ongoing oxidative process in pediatric migraineurs even during attack-free period. This result may shed light on further studies analyzing dynamic changes in the oxidant-antioxidant balance during the attack and the aura phase to support the presence and importance of oxidative stress in pediatric migraine.
Keywords : çocuk, migren, tiyol disülfit

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