New determinants for causal neural mechanism of dry mouth in Parkinson’s disease induced by destruction of superior salivatory nucleus, facial nerve, and submandibular gland circuitry: an experimental study

Authors : Mete ZEYNAL

Pages : 153-159

Doi:10.38053/acmj.1242763

View : 14 | Download : 7

Publication Date : 2023-03-27

Article Type : Research Paper

Abstract :Aim: Dry mouth has been considered a clinical finding of Parkinson’s disease insert ignore into journalissuearticles values(PD);, but we think otherwise. We studied if the olfactory bulbectomy insert ignore into journalissuearticles values(OBX); might rely on the superior salivatory nucleus insert ignore into journalissuearticles values(SSN);, submandibular ganglia insert ignore into journalissuearticles values(SMGn);, and submandibular glands insert ignore into journalissuearticles values(SLGl); circuity disruption induced submandibular gland degeneration related dry mouth in rats. Material and Method: This study was carried out on twenty-six male rats. Five insert ignore into journalissuearticles values(GI-n=5);, six insert ignore into journalissuearticles values(GII, n=6);, and sixteen insert ignore into journalissuearticles values(GIII, n=15); of them were used as control, SHAM, and OBX groups, respectively, and followed eight weeks. PD-related clinical examinations were done before and after the experiment insert ignore into journalissuearticles values(1/day);, and animals were decapitated. The olfactory bulb volumes insert ignore into journalissuearticles values(mm3);, degenerated neuron densities of SSN/SMG insert ignore into journalissuearticles values(n/mm3 and SMGl follicles volumes were detected serologically. Olfactory bulb volume values and degenerated neuron density values of SSN/SMGn/SMGl follicles volumes were compared statistically. Results: OBX-applied animals showed anosmia, tremors, rigidity, and memory loss. The mean olfactory bulb volumes insert ignore into journalissuearticles values(mm3);, degenerated neuron density of SSN insert ignore into journalissuearticles values(n/mm3);, SMGn insert ignore into journalissuearticles values(n/mm3);, and follicles volumes of SMGl insert ignore into journalissuearticles values(cubic micrometer/mm3); were measured in the order written as; insert ignore into journalissuearticles values(4.27±0.21);, insert ignore into journalissuearticles values(4±1);, insert ignore into journalissuearticles values(5±2);, insert ignore into journalissuearticles values(81.23±13.34);.106 in GI; insert ignore into journalissuearticles values(3.67±0.33);, insert ignore into journalissuearticles values(14±3);, insert ignore into journalissuearticles values(17±4);, insert ignore into journalissuearticles values(72.45±11.78);.106 in GII and insert ignore into journalissuearticles values(2.91±0.14);, insert ignore into journalissuearticles values(23±5);, insert ignore into journalissuearticles values(29±8);, insert ignore into journalissuearticles values(57.19±11.93);.106 in Group III. The mean P values between olfactory bulb volumes, degenerated neuron densities of SSN and SMGn, and salivary follicles volumes were: p<0.005 in GI/GII; p<0.0005 in GII/GIII; p<0.0001 in GI/GIII. Conclusion: OBX-related olfactory network designalisation may be responsible for SSN/SMGn circuitry degeneration-induced SMGl atrophy-based dry mouth. The OBX-related dry mouth should be considered a causative factor for Parkinson’s disease, not a result.
Keywords : Olfactory bulbectomy, salivatory nucleus, submandibular ganglion, facial nerve, salivary gland