Does Serum Delta FSH Level Provided with High Starting Dose FSH Differ Among Various Ovarian Responses?

Authors : Işıl Kasapoğlu, Kiper Aslan, Cihan Çakır, Göktan Kuşpınar, Berrin Avcı, Berke Oral, Gürkan Uncu
Pages : 375-380
Doi:10.32708/uutfd.1481616
View : 52 | Download : 47
Publication Date : 2025-01-12
Article Type : Research Paper
Abstract :The objective of this study is to evaluate whether serum delta FSH levels (the percentage difference of serum FSH between antagonist starting day and basal serum FSH level) differ between patients with different COH responses (poor, suboptimal response and normoresponders) who stimulated with a high (300 IU) fixed recombinant FSH dose during flexible antagonist cycles. This study is a retrospective cross sectional cohort study conducted in a tertiary ART Center. 122 women were evaluated, of which, 51 were poor responders, 52 had suboptimal response and 19 had normal response. The primary outcome is to evaluate the spot serum FSH levels on the first day of GnRH antagonist dose administration and the delta FSH levels between groups. Basal serum FSH levels differed significantly between (7[5.2-8.6], 5.7[4.6-7.2], 4.8[4.1-5.3] poor, suboptimal and normoresponders respectively; p<0.001). Median spot serum FSH level on the antagonist starting day was significantly lower in normoresponders than poor and suboptimal responders (p=0.001 and p=0.025). Delta serum FSH levels did not differ significantly between groups (p=0.39). Rate of response to COH was significantly higher for the normoresponder group compared to poor and suboptimal groups (p<0.001 and p=0.019). Delta serum FSH levels were positively correlated with the response to COH (r=0.24, p=0.008). Although Delta serum FSH percentage did not differ between groups, normoresponder patients had a better response to COH. In conclusion, poor responders are not positively affected by a high dose of FSH exposure due to the fact that poor responders have a limited number of antral follicles that have already been exposed to high levels of FSH.
Keywords : Serum Fsh düzeyleri, Kontrollü over stimülasyonu, IVF, ICSI, Over rezervi

ORIGINAL ARTICLE URL