The Changes in LDH Activity in Various Tissues of Rats Exposed to Fenarimol

Fenarimol is a fungicide widely used in fruit and vegetable cultivation, particularly in vineyards, to combat fungal diseases. Exhibiting both estrogenic and antiandrogenic activities, this compound also influences several key enzymes, including gamma-glutamyltransferase, glucose-6-phosphatase, and alkaline phosphatase. In the present study, the enzyme lactate dehydrogenase (LDH) was selected as a biochemical marker to evaluate tissue-specific effects of Fenarimol exposure. Fenarimol was administered intraperitoneally to both male and female rats at its LD₅₀ dose (200 mg/kg). Following administration, changes in LDH enzyme activity were assessed in liver, kidney, brain, and small intestine tissues at various time intervals: 2, 4, 8, 16, 32, 64, and 72 hours. The results indicated a significant increase in LDH activity in all examined tissues post-exposure. However, this elevated enzyme activity gradually declined toward the 72-hour mark in both sexes. These increases in LDH activity suggest that Fenarimol induces notable tissue damage, reflecting its toxicological impact on vital organs.