Effect of oleuropein on element distributions in liver of diabetic rats

Authors : Funda KARABAĞ ÇOBAN, Ali Osman ALBAYRAK

Pages : 1-9

View : 108 | Download : 10

Publication Date : 2018-06-28

Article Type : Research Paper

Abstract :There is accumulating evidence demonstrating that the metabolism of many trace elements is modified in diabetes mellitus. In addition, essential elements and minerals are key to nutrition and sound health. Oleuropein, a major phenolic compound in olives, is known to reduce the blood glucose levels in alloxaninduced diabetic rats and rabbits. The purpose of this study was to compare the levels of essential trace elements, selenium insert ignore into journalissuearticles values(Se);, manganese insert ignore into journalissuearticles values(Mn);, copper insert ignore into journalissuearticles values(Cu);, chromium insert ignore into journalissuearticles values(Cr); and zinc insert ignore into journalissuearticles values(Zn); in St repsttozotocin insert ignore into journalissuearticles values(STZ);-induced d iabetic rats and to evaluate the effects of oleuropein on trace elements levels. Animals were apportioned into 4 groups of 8 rats each. The control group was fed with standard rat provender and got no added treatment. In the oleuropein group, 20 mg/kg dosages of oleuropein were given to normal animals intraperitoneally insert ignore into journalissuearticles values(i.p); for 28 days. In the diabetic group, STZ was injected to rats at a single dose of 50 mg/kg i.p. The last group, 20 mg/kg dosages of oleuropein were given to diabetic animals i.p for 28 days. In this study, trace elements levels were evaluated by using ICP-MS and MDA, SOD CAT levels were evaluated by using spectrophotometers methods. Trace elements levels were significantly insert ignore into journalissuearticles values(p <0,05); decreased in diabetic rats liver but oleuropein was significantly insert ignore into journalissuearticles values(p<0,05); increased trace element levels in this group. In the diabetic group, serum blood glucose levels were significantly insert ignore into journalissuearticles values(p <0,05);  increased and STZ increased t otal oxidant status insert ignore into journalissuearticles values(TOS);, malondialdehyde insert ignore into journalissuearticles values(MDA); in the liver, whereas it decreased superoxide dismutase insert ignore into journalissuearticles values(SOD); and catalase insert ignore into journalissuearticles values(CAT); and total antioxidant capacity insert ignore into journalissuearticles values(TAS); in diabetic rats liver. As a consequence, oleuropein treatment shows an antioxidant and in diabetes by reducing oxidative stress and it was increased trace element levels.
Keywords : Rat, diabetes, element, oleuropein

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