The Antibiotic Resistance Patterns of Pseudomonas Aeruginosa Strains Isolated from Microbiological Specimens

Authors : Duygu Kübra TUNA

Pages : 152-159

Doi:10.52976/vansaglik.1220794

View : 58 | Download : 32

Publication Date : 2023-08-30

Article Type : Research Paper

Abstract :Purpose: This single-center retrospective study involving the data of human participants aimed to determine the antibiotic resistance rates of Pseudomonas aeruginosa strains isolated from samples collected by the microbiology laboratory for four years. Methods: The samples of wound, blood, tracheal aspirate, abscess, vagina, cerebrospinal fluid, sputum, and urine culture isolated from 789 patients who were hospitalized in the service, intensive care and outpatient services between 2017-2021 were evaluated retrospectively for Pseudomonas species. Results: Most of culture were urine insert ignore into journalissuearticles values(42.7%); and sputum cultures insert ignore into journalissuearticles values(20.4%);. Most patients applied to the service were transferred from department of chest diseases insert ignore into journalissuearticles values(38.6%); or from department of urology insert ignore into journalissuearticles values(14.3%); or palliative care unit insert ignore into journalissuearticles values(12.5%);. The highest rates of resistances were against cefuroxime, levofloxacin and netilmicin; lowest rate of resistance was against amikacin. The resistances against aztreonam, cefepime and gentamicin significantly reduced over years insert ignore into journalissuearticles values(P=0.0321, 0.0038 and 0.0004, respectively); while resistances against colistin and levofloxacin considerably increased insert ignore into journalissuearticles values(P<0.0001 and P=0.0407, respectively);. Significant decreases were observed in resistances against cefepime, ceftazidime and ciprofloxacin over years insert ignore into journalissuearticles values(P=0.0321, 0.0038 and 0.0004, respectively);. A significant decrease in resistance of strains isolated from urine culture was only observed for cefepime over years insert ignore into journalissuearticles values(P=0.0003);. The resistance of strains isolated from cultures of sputum, urine and respiratory secretions against levofloxacin significantly increased in 2019 while those of wound culture increased in 2020 insert ignore into journalissuearticles values(P=0.0145);. Conclusion: Alterations in the antibiotic resistance profile were detected in patients over years due to frequently varied use of antimicrobials. To select effective treatment protocols, it is necessary to regularly determine the microorganisms and their antibiotic resistance for each hospital
Keywords : Pseudomonas aeruginosa, antibiyotik direnç, suş, kültür

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