Comparison of Bone Morphogenetic Protein -2 Secretion Capacity of Myoma, Myometrium and Endometrium

Authors : Yeliz Aykanat, Fulya Gokdagli Sagir, Lebriz Hale Aktün Tamer, Şükriye Leyla Altuntaş, Betül Dündar, Türkan Yiğitbaşı
Pages : 14-19
Doi:10.52976/vansaglik.1478714
View : 47 | Download : 61
Publication Date : 2025-04-30
Article Type : Research Paper
Abstract :Introduction: Bone morphogenetic protein-2 (BMP-2) is a member of the transforming growth factor β3 (TGF-β3) family and plays a crucial role in decidualization and implantation. Myomas can adversely affect endometrial receptivity and embryo implantation. Recent studies have highlighted the importance of understanding the molecular mechanisms underlying endometrial receptivity. The aim of this study is to determine BMP-2 secretion capacity of intramural, subserous, submucous myomas and their effects on endometrial tissue BMP-2 levels. Material- methods: Ninety-seven women who underwent hysterectomy or myomectomy because of symptomatic myomas were divided into three groups as submucous (SMM, n=26), intramural (IMM, n=34), and subserous (SSM, n=37). Myoma, myometrium and endometrial tissue samples were isolated and homogenized. BMP-2 concentrations of myoma, myometrium and endometrium tissue samples were evaluated with ELISA kits. Results: BMP-2 levels showed no significant difference between myoma samples of SMM, IMM, SSM (p>0,05). Within the groups, endometrium of SMM have the lowest BMP-2 levels (2417±720 pg/ml, p value <0,05). BMP-2 levels in endometrium of SSM and IMM groups were higher than myoma and myometrium of SSM and IMM groups. SMM group did not show any difference in BMP-2 levels in endometrium, myometrium and myoma. Conclusion: Subserous, submucous and intramural myomas show different effect on BMP-2 expression in endometrium, myometrium and myoma. SSM and IMM have no impact on BMP-2 expression of endometrium. But SMM alter release of BMP-2 in endometrium. Decreased BMP-2 levels may be the responsible mechanism for impared implantation and decreased pregnancy rates in this group of patients. Further investigations may lead to the development of novel therapeutics aimed at restoring BMP-2 levels.
Keywords : myom, infertilite, bone morfogenetik proteini-2

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