Efficacy of combination of daily tadalafil and solifenacin in patients with storage symptom predominant lower urinary tract symptoms

Authors : Ahmet HACİİSLAMOĞLU, Abdullah Hızır YAVUZSAN

Pages : 41-47

Doi:10.33719/yud.2023;18-1-1193181

View : 11 | Download : 11

Publication Date : 2023-02-27

Article Type : Research Paper

Abstract :Objective: To evaluate the efficacy of tadalafil 5mg+solifenacin 5mg combination in terms of lower urinary tract symptoms insert ignore into journalissuearticles values(LUTS); and erectile functions in benign prostate hyperplasia patients with predominant storage symptoms. Material and Methods: Male patients over the age of 40 who presented with LUTS with predominant storage symptoms between January 2019 and December 2021 were included into the study. Daily tadalafil 5mg and solifenacin 5mg treatment were started to the patients. Overactive bladder symptom score insert ignore into journalissuearticles values(OABSS);, international prostate symptom score insert ignore into journalissuearticles values(IPSS); for LUTS, and international erectile function index-erectile function insert ignore into journalissuearticles values(IIEF-EF); questionnaires were used for erectile function. Frequency of daily urinary frequency, frequency of nocturia, urgency and urinary incontinence were analyzed with a three-day bladder diary. Twelve weeks later, IPSS, OABSS and IIEF-EF scores of the patients were evaluated. Results: When the symptom scores and bladder diaries of the patients before and after 12 weeks of treatment were compared, significant decrease in IPSS scores insert ignore into journalissuearticles values(both voiding, storage and total); insert ignore into journalissuearticles values(p<0.001 for each);, significant increase in IIEF-EF scores insert ignore into journalissuearticles values(p<0.001);, and significant increase in Qmax value elevation was observed. When the bladder diaries were compared, the number of daytime micturitions, the number of nocturia and the number of urgency decreased in the 12th month after tadalafil+solifenacin treatment insert ignore into journalissuearticles values(p<0.001);. Conclusion: The combination of tadalafil 5mg and solifenacin 5mg daily is an effective and safe treatment for male patients with storage symptoms predominant LUTS/ED.
Keywords : benign prostat hiperplazisi, depolama, tadalafil, solifenasin, erektil fonksiyon