Bibliometric Analysis on Methods and Tools Developed for DGE Analysis: Current Trends and Future Perspectives

Authors : Necla Koçhan

Pages : 78-91

Doi:10.53433/yyufbed.1591489

View : 31 | Download : 36

Publication Date : 2025-04-29

Article Type : Research Paper

Abstract :Differential gene expression (DGE) analysis has gained significant attention with the advent of next-generation sequencing technologies, leading to the development of a wide range of methods and tools for DGE analysis. We performed bibliometric analysis using Biblioshiny and VOSviewer software to investigate the trends over the investigated period. Relevant papers with differential gene expression related terms as the subjects from 2005 to 2023 were retrieved from the Web of Science database. Network maps were generated using Biblioshiny and VOSviewer software to illustrate the published trends over the investigated period. A total of 729 studies were examined to reveal trends in the DGE analysis methodologies, tools, and packages. In the analysis, co-authorship, bibliographic coupling, and co-occurrence analyses were conducted for country, institution, source, author, and keyword productivity. It was found that the output and citation numbers increased after 2005. During the study period, the USA and China emerged as the leading contributors to the field. The temporal study revealed a significant increase in publications at certain times, followed by period of slight decrease. The greatest fall was observed between 2008 and 2010. Despite these decreases, DGE analysis remains a critical topic in genomics due to its essential role in understanding the mechanisms of any disease, gene function, and therapeutic targets. This trend suggests that current methods and tools are considered sufficiently powerful for identifying key informative genes associated with diverse diseases.
Keywords : Bibliyometrik analiz, Diferansiyel dizileme analizi, Diferansiyel gen ekspresyonu, Gen ifadesi, RNA-dizileme