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  • Ankara Üniversitesi Eczacılık Fakültesi Dergisi
  • Volume:23 Issue:1
  • COHb and MetHb Levels in Victims of CO Poisoning and Cigarette Smokers

COHb and MetHb Levels in Victims of CO Poisoning and Cigarette Smokers

Authors : Nevin VURAL, Rukiye KAHRAMAN
Pages : 11-20
Doi:10.1501/Eczfak_0000000147
View : 48 | Download : 11
Publication Date : 1994-06-01
Article Type : Research Paper
Abstract :CO zehirlenmesi sonucu ölen kişilerin (n:18) kanında postmor­tem karboksihemoglobin (COHb) tayini Dubovvski'nin spektrofotometrik yöntemi ile yapılmıştır. Ayrıca COHb yanında methemoglobin (MetHb) miktarı da spektrofotometrik yöntem ile araştırılmıştır. Postmortem kan Örneklerinde COHb düzeyi % 63-88 arasında (orta­lama % 73.11 ± 6.90) ve MetHb düzeyi ise % 0.86-4.20 arasında (ortalama % 3.00 ± 0.87) bulunmuştur. Kan örneklerindeki COHb ve MetHb konsantrasyo alarmda, buzdolabı sıcaklığında 2 ay süreli bekletmenin ve heparin ilavesinin anlamlı bir kayba yol açmadığı gözlenmiştir (P > 0.05). Ayrıca CO'e kronik maruz kalan kişilerde (sigara içenlerde n: 100) COHb ve M e t H b düzeyleri aynı yöntemle yapılmıştır. COHb ve MetHb düzeyleri, günde 1-9 tane içenlerde (n: 44) % 1.94 ± 0.11 COHb, % 1.19 ± 0.05 MetHb, 10-20 tane içenlerde (n: 23) % 3.25 ± 0 . 1 9 COHb, % 1.47 ± 0.06 M e t H b ve > 20 tane içenlerde ise (n: 31) % 4.36 ± 0.14 COHb, % 1.55 ± 0 . 1 4 MetHb belirlenmiştir. COHb düzeyi sigara içen tüm gruplarda içmeyenlere göre ( % 0.86 ± 0.05) anlamlı yüksek bulunmuştur (P < 0.01, P < 0.05). bowski's spectrophotometric method. Occurence of methemoglobin (MetHb) in postmortem blood was also investigated by spectrophotometric method. COHb and MetHb levels of postmortem blood samples were found between 63.00-88.00 % (mean 73.11 ± 6.90 %) and 0.864.20 % (mean 3.00 ± 0.87%) respectively. COHb and MetHb levels of the subjects (cigarette smokers n: 100) who exposed to low CO were also determined by the spectrophotometric method mentioned above. COHb and MetHb levels of the smokers were found 1.94 ± 0.11 % COHb and 1.19 ± 0.05 % MetHb who smoked 1-9 cigarettes daily (n: 44), 3.25 ± 0.19 % COHb and 1.47 ± 0.06 % MetHb who smoked 10-20 cigarettes daily (n: 23), 4.36 ± 0.14 % COHb and 1.55 ± 0 . 1 4 % MetHb who smokers in all groups were found significantly higher than the nonsmokers (P < 0.01, P < 0.05)
Keywords : Karbonmonoksit, karboksihemoglobin, methemoglobin, zehirlenme, spektrofotometre

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