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  • Ankara Üniversitesi Eczacılık Fakültesi Dergisi
  • Volume:17 Issue:1
  • Effect of Rutin on the Isolated Rat Duodenum and Comparison with the Effects of Adrenaline, Isoprena...

Effect of Rutin on the Isolated Rat Duodenum and Comparison with the Effects of Adrenaline, Isoprenaline and Papaverine

Authors : Orhan ALTINKURT, Yusuf ÖZTÜRK
Pages : 49-56
Doi:10.1501/Eczfak_0000000122
View : 26 | Download : 16
Publication Date : 1987-06-01
Article Type : Research Paper
Abstract :Deneyler izole sıçan duodenum u kullanılarak sürdürüldü. Doğa l bir flavonoid bileşiği olan rutin doza bağımlı biçimde sıçan duodenumun u gevşetti. Rutin'i n sıçan duodenumundak i gevşetici etkisi adrenalin, izoprenalin ve papaverin ile karşılaştırmalı olarak incelendi. Ayrıca, rutin'in sıçan duodenumundak i gevşetici etkisinin mekaniz -masını araştırmak için beta-adrenerjik bloker olan propranolol, alfaadrenerjik bloker olan fentolamin ve bir adenil siklaz inhibitörü olan nikotinik asid de kullanıldı.
Keywords : Rutin, Adrenaline, Isoprenaline, Papaverine, Phento lamine, Propranolol, Nicotinic acid, Smooth muscle

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