SYNTHESIS AND STRUCTURE ELUCIDATION OF NEW METHYL 1H-BENZIMIDAZOLE-5-CARBOXYLATE DERIVATIVES

Authors : Fatıma DOĞANÇ

Pages : 490-496

Doi:10.33483/jfpau.1249200

View : 19 | Download : 38

Publication Date : 2023-05-20

Article Type : Research Paper

Abstract :Objective: In this study, in connection with previous works in our department, some methyl 1H-benzimidazole-5-carboxylate derivatives were synthesized for the first time. Compounds were modified by substituting the second position of the benzimidazole ring with 4-methylpiperidinyl groups for increasing antibacterial activity. Material and Method: The targeted methyl 1H-benzimidazole-5-carboxylates were synthesized by the reaction of o-phenylendiamine derivatives with urea. Oxygen at the 2nd position was converted to chlorine in the presence of POCl3. Finally, the resulting products were obtained by the nucleophylic substitution with 4-methylpiperidine. Structures of synthesized compounds were elucidated with 1H- 13C-NMR and LC-MS techniques. Result and Discussion: Methyl 1H-benzimidazole-5-carboxylate derivatives bearing 4-methyl piperidinyl groups at the 2nd position were synthesized to improve better in vitro antibacterial activity profiles. In vitro antibacterial activity of the synthesized compounds in this study is under investigation.
Keywords : 1H 13C NMR, 1H benzimidazol, 4 metilpiperidin, metil 1H benzimidazol 5 karboksilat