TABLETING AND EVALUATION OF MULTIPLE-UNIT COMPOSITION OF ISOSORBIDE DINITRATE WITH MODIFIED RELEASE

Authors : Dmytro Oliinykov, Andrii Kaplaushenko, Olena Kryvoviaz, Olena Toziuk

Pages : 138-149

Doi:10.33483/jfpau.1075143

View : 60 | Download : 85

Publication Date : 2024-01-20

Article Type : Research Paper

Abstract :Objective: This study was aimed to create a multiple-unit dosage form of isosorbide dinitrate by pressing spherical matrix granules into tablets, selecting the optimal technology parameters and evaluating the obtained tablets. Material and Method: The tablet cores were prepared from mixtures of active matrix granules and shock-absorbing auxiliary granules in various ratios using diverse tabletting forces. The dissolution profiles of the obtained tablet compositions were evaluated in comparison with the reference preparation. Result and Discussion: An optimal ratio of spheroids with the active component with auxiliary granules along with optimal compression parameters were determined. The resulting as multiple-unit tablets exhibited a release profile similar to that of Cardicket Retard. Used technological approach makes it possible to regulate the dissolution profile of tablets by changing the ratio of active granules with different kinetics of the active substance release.
Keywords : Aktif maddenin salım profili, izosorbid dinitrat, küresel matris granülleri, multidozlu tabletler