THE PROMISING ROLE OF iNOS INHIBITORS IN ALZHEIMERS DISEASE

Authors : Shkar Mariwan Ahmed, Gulcin Tugcu, Meric Koksal Akkoc

Pages : 289-299

Doi:10.33483/jfpau.1314900

View : 128 | Download : 155

Publication Date : 2024-01-20

Article Type : Review Paper

Abstract :Objective: This study aims to explore the role of iNOS inhibitors in Alzheimer\'s disease (AD), a neurodegenerative disorder affecting millions worldwide. The main symptoms of AD include memory loss, cognitive decline, and behavioral changes. While the exact cause remains uncertain, both genetic and environmental factors are believed to contribute. Recent research has emphasized the significance of nitric oxide (NO) in AD development. Specifically, the upregulation of inducible nitric oxide synthase (iNOS) in AD patients leads to excessive NO production during neuronal inflammation, exacerbating AD and dementia. Therefore, the investigation focuses on the potential of iNOS inhibitors as a novel therapeutic approach for AD treatment. Result and Discussion: In this review, we present the current therapeutic strategies available for Alzheimer\'s disease (AD) and explore the promising potential of iNOS inhibitors in AD treatment. Specifically, we will focus on their capacity to mitigate NO production and examine their potential neuroprotective effects. Additionally, this review will offer an overview of both natural and synthetic iNOS inhibitors, emphasizing the importance of safety considerations during the development of iNOS inhibitors as therapeutic interventions for AD.
Keywords : Alzheimer hastalığı, iNOS, nöroenflamasyon, nitrik oksit

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