EVALUATING THE ROLE OF MELATONIN ON THYROID PHYSIOLOGY AND DISEASES

Authors : Özlem Öztürk Ceylan, Beyza Yılmaz, Sibel Süzen

Pages : 1281-1292

Doi:10.33483/jfpau.1504455

View : 51 | Download : 64

Publication Date : 2024-09-10

Article Type : Review Paper

Abstract :Objective: Melatonin (MLT) is largely produced within the pinealocytes from tryptophan, happening during the dark. MLT’s binding sites have been established in numerous parts of the brain but also in the cells of the immune system, gonads, kidney, and cardiovascular system. MLT may directly or indirectly affect the thyroid gland and its activities. It can also prevent thyroid cell proliferation and interfere with thyroid hormone synthesis. The underlying mechanisms need to be carefully interpreted. Result and Discussion: In this review the typical inhibitory effects of MLT on the thyroid gland and hormone secretion, as well as its antioxidant effects and relationship with thyroid diseases is investigated.
Keywords : Hipotiroidizm, melatonin, melatonin reseptörleri, tiroid kanseri, tiroid fizyolojisi