A VALIDATED ADSORPTIVE STRIPPING DIFFERENTIAL PULSE VOLTAMMETRIC METHOD FOR THE QUANTIFICATION OF LINAGLIPTIN FROM URINE SAMPLE

Authors : Ali Kemal Ateş

Pages : 809-816

Doi:10.33483/jfpau.1660133

View : 54 | Download : 60

Publication Date : 2025-09-19

Article Type : Research Paper

Abstract :Objective: In this study, a low-cost, sensitive and practical electroanalytical method was developed and validated for the determination of Linagliptin (LNG), a therapeutic agent used in the treatment of Diabetes Mellitus, one of the most common chronic diseases worldwide, characterized by high blood glucose levels and directly affecting millions of people. Material and Method: Electroanalytical studies were completed using screen-printed carbon electrodes in pH: 8 Britton - Robinson buffer solution. Mechanistic studies were carried out by cyclic voltammetry technique. Adsorptive stripping differential pulse voltammetry technique was used for the electrochemical determination of LNG. Result and Discussion: The developed method exhibited linearity in the range of 0.1 - 7.5 µM and the limit of detection value was calculated as 37 nM. The developed method was applied for the determination of LNG from urine and a recovery value of 100.02% was obtained.
Keywords : Adsorptive sıyırma diferansiyel puls voltametri, antidiyabetik ilaç, elektrokimyasal analiz, linagliptin

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